You'll have to calibrate the throttle to the ESC. The instructions will tell you how to tell the ESC what's full throttle, neutral, and full brake. I found out that some ESC's calibrate differently. Castle for example is different from HobbyWing.
The program card only programs the funtions like punch, brake strength, etc. I'd try it with the default settings and see how you like it. I have never programmed mine, ran great out of the box.